FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF PERAMPANEL IMMEDIATE RELEASE TABLETS

The aim of the present study is to develop and evaluate the immediate release tablet of Perampanel by direct compression method. The superdisintegrant crospovidone (CP), croscarmellose sodium (CCS) and sodium starch glycolate (SSG) were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drug excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F3 exhibit highest dissolution using crospovidone showed faster drug release 99.13 % over the period of 45min.