ASSESSMENT OF DRUG PRESCRIPTION PATTERN IN ST-SEGMENT AND NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS

Dr. Ahmadi Banu¹, Nizampuram Bhavani², Tekulapally Pavani Brundha^3*, Vanjari Indumathi⁴ 

1.Vishnu Institute of Pharmaceutical Education and Research, Assistant Professor, Department of pharmacology, Vishnupur, Narsapur, Medak, India. 2,3,4. Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, India.

Corresponding Author: Tekulapally Pavani Brundha, Vishnu Institute of Pharmaceutical Education and Research, Department of pharmacology, Vishnupur, Narsapur, Medak, India, Email: pavanibrundha007@gmail.com.

Citation: Dr. Ahmadi Banu¹, Nizampuram Bhavani², Tekulapally Pavani Brundha^3*, Vanjari Indumathi⁴ (2024). Assessment of Drug Prescription Pattern in Patient Who were Diagnosed with ST and Non-ST Segment myocardial infraction. Eco Science Journal.2024 1(5).

Copyrights © 2024, Dr. Ahmadi Banu. This article is licensed under the Creative Commons Attribution-NonCommercial-4.0-International-License-(CCBY-NC)

Abstract

Background: An assessment of drug prescription pattern in patients who were diagnosed with ST and Non-ST Segment myocardial infarction and who met the inclusion criteria and exclusion criteria was carried out in the Malla Reddy Narayana Multispecialty Hospital, Hyderabad.

Aim: To study drug prescription patterns in patients with ST and Non ST- segment elevation myocardial infarction.

Methods: A prospective observational study for a period of 5 months was conducted in the cardiology department of Malla reddy hospital. The percentage of the data was calculated using Microsoft Excel 2016.

Results: A total number of 55 patients were enrolled in the study of which 36 [65%] were male patients and 19 [35%] were female patients. The NSTEMI patients are more in number when compared to STEMI patients. The age group between 50-70 are mostly facing MI and later comes the 40-49 age population. While, 20- 30 years age group are seen in exceptional cases with other diseases being main cause [ blood clots]. The drugs prescribed for STEMI and NSTEMI in India are LIPIVAS[Statin] with 75% prescribed for patients. Then comes the ECOSPRIN [Anti-platelet medicine] prescribed for 70% of patients, CLOPIVAS [Anti-platelet medicine] prescribed for 65% of patients, MITNOX [Anticoagulant] for 63%, AGGXIBLOC and METODER [β-BLOCKER] with 50% prescribed. And MAVIK [ACE inhibitor] with least i.e., 45% prescribed. The overall prescription patterns involved in our study is satisfactory.

The objective of present study was to formulate and evaluate bilayer tablet of Almotriptan malate (AM) and Diclofenac potassium (DP) for the effective treatment of migraine. The combination of almotriptan malate and diclofenac potassium is used as almotriptan malate establishes the immediate release layer (initialdose) and diclofenac potassium as the sustained release layer (maintenance dose) respectively. The bilayer tablets of AM and DP was particularly designed to minimize the risk of rebound migraine and improve the therapeutic efficacy and to prolong the release of drug and patient compliance. Formulation variables for immediate release layer include sodium starch glycolate and crospovidone as super disintegrants and micro crystalline cellulose as filer. HPMC K100, HPMC K15, was used as sustained release polymers. The result of in-vitro release data showed that HPMC K15 and HPMC K100 combination can sustain the drug release up to 12hrs. From these studies HPMC K15 and HPMCK100 combination has been selected for further studies of bilayer tablet. Almotriptan malate and diclofenac potassium bilayer tablet were prepared by direct compression method. The hardness of the bilayer tablets was 6.30±0.17kg/cm². The thickness of the bilayer tablets was 5.19±0.10mm. The drug content of Almotriptan malate and Diclofenac potassium was 98.10±0.90 (SR) and 98.84±0.09 (IR). The in-vitro drug release of bilayer tablets have Almotriptan malate immediate release was within 45minutes and Diclofenac release from the tablets was found sustained over 12 hours with Zero order equation to analyze the release pattern of the drug from the polymeric system. The value of “n” were in the range of 8.0454, indicating the drug release followed Super case-II transport diffusion, possibly owing to chain distanglement and swelling of hydrophilic polymer. The Fourier transform infrared spectroscopy (FT-IR) analyses indicated that there was absence of any chemical interaction between the drugs and excipients.

The results of Accelerated stability studies showed that all parameters were within the expected specifications and there was no significant changes observed from initial to 2month, indicating good stability.

                Thus, the objective of bilayer drug delivery system of anti-migraine drug almotriptan malate and diclofenac potassium with sustained release profile was achieved.

 Keywords: Myocardial infarction, Cardiology society of India, Prescription pattern, ST- segment, Non ST- segment.